id: 35351
Title: Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog
Authors: Zhelavskyi M., Kernychnyi S., Betlinska T.
Keywords: Dog, Discoid lupus erythematosus, Treatment
Date of publication: 2024-03-18 11:45:12
Last changes: 2024-03-18 11:45:12
Year of publication: 2023
Summary: Discoid lupus erythematosus is lupus in dogs an autoimmune disease that affects the skin. A 6-year-old, 38 kg, male German Shepherd Dog was taken to the Small Animal Hospital at the University in Kyiv, Ukraine with a history of progressive skin lesions. The indications of discoid lupus erythematosus in dogs manifested as red, scaly macules or papules on the skin`s surface. These gradually develop into follicular plugging, disc-shaped plaques with adherent scales, and peripheral hyperpigmentation. The oral hydroxychloroquine was used for medication and the prescribed dosage was 5.0 mg per kilogram of the dog`s weight, administered once daily. The hydroxychloroquine was gradually reduced and discontinued within a month. Concomitant with the hydroxychloroquine treatment, the application of tacrolimus cream (Protopic® 0.03%) was initiated. The veterinary physician also advised the dog owner to limit sun exposure to avoid any adverse effects. After a four-week period, there was a decrease in pruritus and erythema, and plaques had flattened although the skin still had some patchy hyperpigmentation. Approximately 3-4 weeks later, the veterinarian determined that the dog had achieved clinical remission as all the skin lesions had become completely flattened. The use of deproteinized calf blood extract gel (Solcoseril® Gel for external 4.15 mg/1 g, Legacy led to the complete disappearance of the initial redness and prevented the appearance of new skin lesions. These results can be considered as a safe and effective alternative to conventional treatment methods.
URI: http://socrates.vsau.org/repository/getfile.php/35351.pdf
Publication type: Статті Scopus
Publication: World’s Veterinary Journal. 2023. Vol. 13, Issue 2. P. 360-364. DOI: https://dx.doi.org/10.54203/scil.2023.wvj39
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Published by: Адміністратор
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